tyrosine-protein kinase Kit, also known as CD117 or mast/stem cell growth factor receptor (SCFR) - a proto-oncogene that interacts with cell growth factors, c-Kit plays a role in cell survival, multiplication and differentiation. Cancers that may benefit from testing for this biomarker: GIST (gastrointestinal stromal tumor), skin (melanoma), blood (acute myelogenous leukemia)

imatinib (Gleevec®), sorafenib (Nexavar®), sunitinib (Sutent®)