MGMT

O-6-methylguanine-DNA methyltransferase - a gene that encodes a DNA repair enzyme, loss of MGMT may play a role in cancer formation, MGMT can also interfere with treatments that work by disrupting tumor DNA. Cancers that may benefit from testing for this biomarker: breast, lung (non-small cell), esophageal, brain (glioblastoma multiforme, oligodendrogliomas), skin (melanoma), pituitary gland (carcinoma)

lack of response to temozolomide (Temodar®)